Diclofenac Sodium 75 mg Injection is a painkiller used to relieve pain and swelling associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, low back pain, and neck pain. It is also effective for pain relief in post-operative patients. 

ALLIDIC-AQ INJECTION 

“Diclofenac Sodium 75 MG Injection is a painkiller used to relieve pain and swelling associated with osteoarthritis (tender and painful joints due to wear down of protective cartilage between the ends of the bones), rheumatoid arthritis (a type of arthritis affecting the small joints of the body), ankylosing spondylitis (pain and stiffness of bones of the spine), low back pain, neck pain, etc. It is also used in post-operative patients for pain relief. Diclofenac Sodium 75 MG Injection blocks the formation of chemical substances in the body that cause swelling and pain. It is a nonsteroidal anti-inflammatory drug (NSAID)“.

composition:

Diclofenac Sodium I.P. 75mg 

Uses

1. Pain Relief: Primarily used to relieve moderate to severe pain, such as post-surgical pain, musculoskeletal pain, or pain due to inflammatory conditions like arthritis.

2. Anti-inflammatory: Helps reduce inflammation in conditions like rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.

Dosage

• Typical Adult Dose: 75 mg administered via intramuscular injection, often given once or twice daily. Dosage and frequency depend on the severity of pain and doctor’s guidance.

• Duration: Typically used for short-term pain relief (1-2 days); if longer treatment is needed, other forms are usually prescribed.

Mechanism of Action

• COX-1 & COX-2 Inhibition: Diclofenac inhibits both COX-1 and COX-2 enzymes, reducing the production of prostaglandins, thromboxanes, and prostacyclins, which are involved in inflammation, pain, and fever.

• Selective COX-2 Inhibition: It has a higher selectivity for COX-2, which helps reduce inflammation and pain, with fewer gastrointestinal side effects.

• Pain Relief: Diclofenac decreases peripheral pain receptor sensitivity and lowers levels of substance P, a pain mediator.

• Anti-inflammatory: Reduces inflammation in tissues, especially in conditions like arthritis.

Side Effects

1. Gastrointestinal: Nausea, vomiting, stomach pain, or indigestion.

2. Injection Site Reactions: Pain, redness, or swelling at the injection site.

3. Dizziness and Headache: Some patients may experience dizziness or headaches.

4. Blood Pressure Changes: May cause an increase in blood pressure.

5. Serious Effects (rare): Risk of stomach ulcers, bleeding, kidney dysfunction, or liver issues.

Precautions

1. Allergic Reactions: Avoid if allergic to diclofenac or other NSAIDs.

2. Gastrointestinal Issues: Use cautiously if there’s a history of stomach ulcers, acid reflux, or gastrointestinal bleeding.

3. Kidney and Liver Conditions: Should be used carefully in patients with kidney or liver disease.

4. Heart Conditions: May increase the risk of heart attack or stroke with prolonged use.

5. Pregnancy and Breastfeeding: Not recommended, especially in the third trimester. Use only if prescribed by a healthcare provider.

**Always use this medication under medical supervision and report any adverse effects immediately.