Amino Acid Injection 7% w/v is used for parenteral nutrition to provide essential amino acids to patients who cannot consume food orally, support protein synthesis in those with protein deficiencies, and aid recovery from severe stress, burns, or malnutrition. 

AMINO NEPHRO INJECTION

“Amino Acid Injection 7% w/v is an intravenous solution offering essential, semi-essential, and non-essential amino acids for patients who cannot meet their protein needs through oral or enteral intake. It’s widely utilized in renal insufficiency to replenish amino acids lost during dialysis and support patients on low-protein diets. Additionally, it aids recovery in cases of critical illness or post-surgery, addressing protein-energy malnutrition, and forms an integral part of parenteral nutrition for those with severe malabsorption or gastrointestinal conditions. Dosages are tailored to individual needs and clinical conditions, administered via peripheral or central veins“.

COMPOSITION:

Amino Acid Injection 7% w/v (EACH 100 ML CONTAINS:)

L-Isoleucine USP   0.510 g
L-Leucine USP     1.030 g
L-Lysine Monoacetate USP equivalent to L-Lysine  0.710 g
L-Methionine USP   0.280 g
L-Phenylalanine USP  0.380 g
L-Threonine USP  0.480 g
L-Tryptophan USP  0.190 g
L-Valine USP 0.620 g
L-Arginine IP  0.490 g
L-Histidine USP  0.430 g
Glycine IP  0.320 g
L-Alanine USP  0.630 g
L-Proline USP  0.430 g
L-Serine USP  0.450 g
Acetyl Cysteine USP equivalent to L-Cysteine  0.037 g
L-Malic Acid IP  0.150 g
Acetic acid, Glacial IP  0.138 g
Water for Injections IP  q.s

Total Amino Acids  70.00 g/L
Total Nitrogen Content  10.80 g/L
Energy Content  287 kcal/L
Osmolarity (calc.)  635 mOsmol/L

Uses:

• Renal Insufficiency:

  • Manages acute and chronic kidney conditions.

  • Compensates for amino acid losses during dialysis (hemodialysis, peritoneal dialysis, hemofiltration).

• Critical Illness and Post-Surgical Recovery:

  • Supports recovery in patients with polytrauma, extensive surgeries, or sepsis.

  • Addresses protein-energy malnutrition by providing building blocks for protein synthesis.

• Low-Protein Diet Supplementation:

  • Supplements amino acids for patients with chronic kidney disease (CKD) on a restricted protein diet.

• Parenteral Nutrition (PN):

  • Administered to patients unable to tolerate oral or enteral feeding due to severe malabsorption or gastrointestinal conditions.

• Nutritional Support for Catabolic States:

  • Aids in protein synthesis during conditions with increased protein breakdown, such as severe infections or burns.

Dosage:

The dosage of Amino Acid Injection 7% w/v is determined based on individual patient needs, including weight, clinical condition, and dialysis status. General guidelines are as follows:

• For Patients Not on Dialysis: Up to 0.5 g of amino acids/kg body weight/day is recommended for acute or chronic renal insufficiency.

• For Patients Undergoing Dialysis (Hemodialysis, Hemofiltration, or Peritoneal Dialysis): Up to 1 g of amino acids/kg body weight/day to compensate for amino acid losses during and after dialysis.

• General Parenteral Nutrition: Dosage varies depending on the patient’s total caloric and protein requirements. Amino acids are typically part of total parenteral nutrition regimens.

Administration:

• Administered intravenously, either via peripheral or central veins.

• The infusion rate should not exceed 20 drops per minute to minimize adverse effects.

Monitoring:

• Regular monitoring of nitrogen balance, renal function, and serum electrolytes is essential to ensure the appropriate dose and prevent complications like hyperammonemia or fluid overload.

• Always consult a healthcare provider for specific dosing tailored to the patient’s condition.

Mechanism of Action:

• Promotes protein synthesis: Amino acids are the building blocks of proteins, essential for muscle growth, repair, and overall body function.

• Enhances wound healing: Supports the repair of damaged tissues.

• Reduces protein catabolism: Decreases the breakdown of proteins in the body, helping maintain muscle mass and strength

Side Effects:

1. Injection Site Reactions: Pain, redness, or swelling at the injection site.

2. Gastrointestinal Issues: Nausea, vomiting, or diarrhea may occur.

3. Fluid Overload: Risk of fluid overload, especially in patients with heart or kidney conditions.

4. Allergic Reactions: Rarely, allergic reactions may occur, leading to symptoms like rash or difficulty breathing.

5. Metabolic Disturbances: Potential for imbalances in electrolytes, particularly in patients with underlying metabolic conditions.

Precautions:

1. Allergies: Avoid use if allergic to any of the amino acids in the formulation.

2. Kidney and Liver Function: Use cautiously in patients with impaired kidney or liver function; dosage adjustments may be necessary.

3. Fluid Management: Monitor fluid balance closely, especially in patients with cardiovascular or renal conditions.

4. Infusion Rate: Administer at the recommended rate to prevent complications related to rapid infusion.

5. Pregnancy and Breastfeeding: Consult a healthcare provider before use in pregnant or breastfeeding women.

**Always administer this injection under the supervision of a healthcare provider and report any unusual symptoms or side effects immediately.