Estnac-P tablets are used for the relief of mild to moderate pain, reduce inflammation, and lower fever, making them effective for conditions like arthritis, headaches, and muscle pain.
composition:
Aceclofenac IP 100mg & Paracetamol IP 325mg
Uses:
Pain Relief: Used to relieve mild to moderate pain, including headaches, toothaches, muscle pain, and pain from arthritis.
Anti-Inflammatory: Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and swelling.
Fever Reduction: Paracetamol helps lower fever and is often used in combination with aceclofenac for added analgesic effect.
Dosage:
Typical Adult Dose:
Aceclofenac: Usually, 100 mg taken twice daily.
Paracetamol: Typically 325 mg taken every 6 hours as needed, not exceeding 3000 mg per day.
Administration: Tablets should be taken with food to minimize gastrointestinal irritation.
Mechanism of Action:
Aceclofenac:
Mechanism: Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. This inhibition reduces the production of prostaglandins, which are substances that mediate inflammation, pain, and fever.
Paracetamol:
Mechanism: Paracetamol (also known as acetaminophen) primarily works by inhibiting COX enzymes in the central nervous system, which increases the pain threshold and reduces fever. Unlike NSAIDs, paracetamol has minimal anti-inflammatory effects and does not significantly inhibit COX enzymes in peripheral tissues.
Side Effects:
Aceclofenac:
Gastrointestinal issues: nausea, vomiting, diarrhea, and abdominal pain.
Dizziness or headache.
Risk of cardiovascular events with long-term use.
Possible liver or kidney issues.
Paracetamol:
Generally well-tolerated, but may cause liver damage in overdose situations.
Rare allergic reactions: skin rash or itching.
Precautions:
Allergies: Avoid use if allergic to aceclofenac, paracetamol, or any components in the formulation.
Liver and Kidney Function: Use cautiously in patients with liver or kidney impairment; monitoring may be necessary.
Gastrointestinal Disorders: Patients with a history of gastrointestinal bleeding or ulcers should consult a healthcare provider before use.
Alcohol Use: Limit alcohol consumption while taking paracetamol due to the increased risk of liver damage.
Pregnancy and Breastfeeding: Consult a healthcare provider before use during pregnancy or breastfeeding.
**Always follow your healthcare provider’s instructions regarding the use of Aceclofenac and Paracetamol and report any unusual symptoms or side effects promptly.