Seizumes-500 Tablets (Levetiracetam IP 500) is an antiepileptic drug used to treat partial-onset, myoclonic, and tonic-clonic seizures in epilepsy. It works by stabilizing abnormal brain activity to prevent seizures
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1. Composition
1. Composition
Active Ingredient: Levetiracetam IP 500mg (antiepileptic drug).
Inactive Ingredients: Excipients vary by brand but commonly include:
Binders: Microcrystalline cellulose, povidone.
Disintegrants: Sodium starch glycolate, crospovidone.
Lubricants: Magnesium stearate.
Coating: Hypromellose, titanium dioxide (for film-coated tablets).
2. Uses
2. Uses
Epilepsy: Treats partial-onset seizures, myoclonic seizures, and generalized tonic-clonic seizures.
Adjunctive Therapy: Used alongside other antiepileptics.
Off-label: Neuropathic pain, migraine prophylaxis (limited evidence).
3. Dosage
3. Dosage
Adults: Start with 500mg twice daily; may increase to 1500–3000mg/day (max dose varies).
Children (>1 month): 10–60mg/kg/day in 2 divided doses (based on weight).
Renal Impairment: Reduce dose (e.g., 50% for CrCl <80 mL/min).
4. Mechanism of Action
4. Mechanism of Action
Binds to synaptic vesicle protein SV2A, modulating neurotransmitter release (reduces hyperexcitability).
Unlike older antiepileptics, it does not affect GABA or sodium channels.
5. Side Effects
5. Side Effects
Common: Drowsiness, dizziness, headache, irritability, infections (e.g., colds).
Serious: Psychiatric effects (aggression, depression, suicidal thoughts), severe rash, hepatitis.
6. Precautions
6. Precautions
Avoid abrupt withdrawal (risk of seizures).
Monitor for mood/behavior changes (especially in children).
Contraindicated in severe hypersensitivity to levetiracetam.
Pregnancy: Use only if benefits outweigh risks (Category C).
7. Evidence & Sources
7. Evidence & Sources
Key Takeaway
Key Takeaway
Levetiracetam IP 500mg is a broad-spectrum antiepileptic with unique SV2A-targeted action. While effective for seizures, monitor for psychiatric side effects and adjust doses in kidney disease. Always follow a doctor’s guidance.
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