MESGABA NT

“Mesgaba NT tablets are primarily used for managing neuropathic pain, such as diabetic neuropathy, post-herpetic neuralgia, and sciatica. They are also effective in treating fibromyalgia and certain chronic pain conditions involving nerve sensitivity. Pregabalin helps by reducing nerve excitability, while Nortriptyline modulates pain perception and improves mood. This combination may also be used in anxiety disorders and depression-associated pain, providing dual benefits of pain relief and emotional stabilization. It is particularly useful for patients needing a comprehensive approach to chronic pain“.

Composition

Pregabalin IP 75mg and Nortriptyline Hydrochloride IP 10mg

Uses

1. Neuropathic Pain: Effective in managing pain from nerve damage, including conditions like diabetic neuropathy and postherpetic neuralgia.

2. Chronic Pain Management: Often used for chronic pain syndromes.

3. Depression: Nortriptyline helps in the treatment of depression, particularly when pain is also a factor.

4. Anxiety Disorders: Both medications can have an adjunctive role in treating anxiety-related conditions.

Dosage

• Initial Dose: Typically, 1 tablet once daily, preferably taken at bedtime to reduce daytime drowsiness.

• Titration: Depending on your response and tolerability, your doctor may adjust the dose, either increasing or decreasing it.

• Maximum Dose: The maximum recommended dose is usually 1 tablet daily, but this can vary based on the condition being treated and individual response.

Mechanism of Action

Pregabalin works by binding to the α2δ subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters like glutamate and norepinephrine, which decreases nerve excitability and alleviates neuropathic pain. Nortriptyline, a tricyclic antidepressant, inhibits the reuptake of serotonin and norepinephrine in the brain, increasing their levels in synaptic clefts. This enhances pain modulation and has antidepressant effects. Together, they target both the physical and emotional components of pain, offering comprehensive relief.

Side Effects

• Drowsiness & Fatigue: You may feel sleepy, dizzy, or tired, especially when starting the medication.

• Dry Mouth & Constipation: Some people may experience dry mouth or trouble with bowel movements.

• Swelling: Swelling in the hands, feet, or legs (edema) can occur.

• Blurred Vision: You might notice your vision becomes blurry.

• Weight Gain: Some individuals may gain weight while using this medication.

• Heart Issues: Rarely, it can cause a faster heart rate or heart rhythm problems.

• Urinary Problems: You may have difficulty urinating or feel like you can’t empty your bladder completely.

• Suicidal Thoughts: There’s a risk of mood changes, including thoughts of harming yourself, especially in younger people.

• Allergic Reactions: In rare cases, you may experience swelling or difficulty breathing.

Precautions

1. Allergies: Avoid if allergic to either pregabalin or nortriptyline.

2. History of Substance Abuse: Both medications may have abuse potential; use cautiously in patients with a history of substance use disorders.

3. Kidney and Liver Impairment: Adjustments may be necessary for patients with renal or hepatic impairment.

4. Pregnancy and Breastfeeding: Consult a healthcare provider before use during pregnancy or breastfeeding.

5. Withdrawal Symptoms: Do not discontinue abruptly, as it may cause withdrawal symptoms. Gradual tapering is recommended under medical supervision.

**Always use these medications under the guidance of a healthcare provider and report any unusual symptoms or side effects immediately.