Uses

• Inflammation & Pain: Acute trauma, post-surgery swelling, osteoarthritis, sports injuries.

• Venous Disorders: Chronic venous insufficiency (CVI), hemorrhoids, varicose veins.

• Edema Reduction: Post-operative/traumatic swelling.

  Dosage

• Adults: Typically 1-2 tablets 3 times daily (varies by formulation; e.g., Trypsin 48mg + Bromelain 90mg + Rutoside 100mg + Diclofenac 50mg).

• Take with food to reduce GI side effects.

• Max Duration: Limited to 7–10 days (due to Diclofenac risks).

Mechanism of Action

Component                                      Action

Trypsin & Bromelain:            Proteolytic enzymes that break down inflammatory proteins,                                                       reduce edema, and enhance fibrinolysis.

Rutoside Trihydrate:          Bioflavonoid that stabilizes capillaries, reduces permeability,                                                     and improves venous tone. 

Diclofenac Sodium:               NSAID inhibiting COX enzymes → reduces prostaglandins                                                          (pain/swelling).

Synergy: Enzymes target protein-based inflammation, Rutoside protects vessels, Diclofenac blocks pain pathways. 

Side Effects

• Common: Nausea, heartburn, diarrhea, dizziness.

• Serious:

  • GI: Ulcers, bleeding (Diclofenac).

  • Renal: Acute kidney injury (NSAID risk).

  • Allergic: Rash, bronchospasm (especially Bromelain in latex-allergic).

  • Bleeding Risk: Enhanced by enzymes + NSAID.

Precautions

• Avoid in:

  • Active GI bleeding/ulcers.

  • Severe kidney/liver disease.

  • Aspirin/NSAID allergy.

  • Latex allergy (Bromelain cross-reactivity).

  • Pregnancy (3rd trimester: Diclofenac contraindicated).

• Monitor: BP, renal function, bleeding signs.

• Drug Interactions:

  • Anticoagulants (warfarin): ↑ Bleeding risk.

  • Diuretics/ACE inhibitors: ↓ Efficacy + nephrotoxicity.

Key Takeaway

This combo targets inflammation, pain, and edema through multi-pathway action but carries significant GI/bleeding risks. Short-term use only under medical supervision.